Conference Programs (ZPPM + Workshop)

4th Zebrafish for Personalized/Precision Medicine Conference (ZPPM)

Wednesday, September 18th, 2019

3:00pm – 6:00pm

Registration and Refreshments (2nd floor, Exhibition Hall)

6:00pm – 6:15pm

Welcome and Opening Remarks (Allan Waters Family Auditorium, Room 209)

ª Dr. Xiao-Yan Wen, Director, ZCADD, St. Michael’s Hospital

ª Dr. Ori Rotstein, VP Research and Innovation, Unity Health Toronto

ª Dr. Mingyao Liu, Director, Institute of Medical Science, University of Toronto

ª Mr. Michael Thompson, Deputy Mayor & Toronto City Councillor

Light Dinner provided

6:15pm – 8:30pm

Session I: Advances in Zebrafish Research & Precision Medicine
Co-chairs: Dr. Xiao-Yan Wen (ZCADD, St. Michael’s Hospital)

                  Dr. Randall Peterson (University of Utah, USA)

6:15pm – 8:15pm

Invited Lectures (25 min + 5 min Q&A)

6:15pm – 6:45pm

Dr. Tugce Balci , Medical Genetics, Schulich School of Medicine & Dentistry, Western University, Ontario, Canada

“ Rare Disease Gene Discovery and Modeling with Care4Rare-SOLVE & RDMM: A Canadian Framework for Precision Medicine ”

6:45pm – 7:15pm

Dr. Sidney Kennedy , Canadian Biomarker Integration Network for Depression (CAN-BIND), UHN & SMH; Dept. of Psychiatry, University of Toronto, Canada

“ Clinical biomarker studies and reverse translation to develop new antidepressant therapies ”

7:15pm – 7:45pm

Dr. Ross Cagan, Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai & Senior Editor of Disease Models and Mechanism, USA

“Wings not fins: A fly-to-bedside approach to personalized cancer therapies”

7:45pm – 8:15pm

Dr. Randall Peterson , Pharmacology & Toxicology, College of Pharmacy, University of Utah, USA

“ Systematic behavioral screening links embryonic chemical exposures with adult social deficits ”

Thursday, September 19th, 2019

7:30am – 8:50am

Registration and Breakfast (2nd floor Exhibition Hall, Room 240 & 241)

9:00am – 12:00pm

Session II: Mutagenesis & Disease Modeling
Chair: Dr. Sarah Childs (University of Calgary, Alberta, Canada)

9:00am – 9:30am

Invited Lecture (25 min + 5 min Q&A):

 

Dr. Koichi Kawakami , Molecular and Developmental Biology, National Institute of Genetics, Japan

“ Transposon-mediated genetic methods in zebrafish and their applications to neuroscience and disease modeling ”

 

9:30am – 10:15am

Oral Presentations (12 min + 3 min Q&A)

 

Dr. Keith C. Cheng, Penn State College of Medicine, USA

“ Work towards an X-ray histotomography imaging resource for whole-organism computational phenomics ”

 

Dr. Xiaolei Xu, Biochemistry and Molecular Biology, Mayo Clinic, Minnesota, USA

“ Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy”

 

Amanda Miles (PhD Candidate), Cell and Systems Biology, University of Toronto, Ontario, Canada

“ Function of the zebrafish type I Usher Syndrome gene, pcdh15b, in photoreceptor maintenance ”

10:15am – 10:30am

Coffee Break (2nd floor, Exhibition Hall)

 

10:30am – 11:00am

Invited Lectures (25 min + 5 min Q&A)

 

Dr. Jamie Gagnon, School of Biological Science, University of Utah, USA

“ CRISPR lineage tracing in the heart and brain”

11:00am – 11:45am

Oral Presentations (12 min + 3 min Q&A)

 

Dr. Kris Vleminckx, Biomedical Molecular Biology, Ghent University, Belgium

“ CRISPR/Cas9 mediated modeling of human cancer in the diploid amphibian Xenopus tropicalis”

 

Sarah Kamel (PhD Candidate), Hubrecht Institute, University Medical Centre Utrecht, The Netherlands

“ Modelling human phospholamban R14del mutation in zebrafish ”

 

Dr. Eric Samarut (Postdoc), CRCHUM, Quebec, Canada

“ Functional genomics of idiopathic epilepsies in zebrafish: from pathogenic mechanisms to customized anti-seizure medication”

12:00pm – 1:00pm

Lunch (2nd floor, Exhibition Hall, Room 240 & 241)

1:30pm – 4:30pm

Session III: Mechanisms of Development, Organ Dysfunction & Disease

Chair: Dr. Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)

1:30pm – 2:00pm

Invited Lecture (25 min + 5 min Q&A)

 

Dr. Cecilia Moens , Fred Hutchinson Cancer Research Center, University of Washington, USA

“ Using the zebrafish to understand the neurodevelopmental basis of speech and swallowing disorders ”

2:00pm – 2:45pm

Oral Presentations (12 min + 3 min Q&A)

 

Dr. Han Wang , Center for Circadian Clocks, Soochow University, China

“ The circadian clock promotes spermatogonial differentiation and fertilization through retinoic acid signalling”

 

Dr. Dimitris Beis , Biomedical Research Foundation Academy of Athens, Greece

“ Zebrafish models of cardiac development, disease models and regeneration ”

 

Arsheen Rajan (MSc Candidate), Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada

“ Perivascular fibroblasts in maintaining blood vessel integrity in zebrafish ”

2:45pm – 3:00pm

Coffee Break (2nd floor Exhibition hall)

3:00pm – 3:30pm

Invited Lecture (25 min + 5 min Q&A)

 

Dr. Jordan Shavit , Department of Pediatrics, University of Michigan, USA

“ Using zebrafish to model disorders of coagulation and develop therapeutics”

3:30pm – 4:15pm

Oral Presentations (12 min + 3 min Q&A)

Dr. Wenbiao Chen, Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, TN, USA

“ Metabolic stress induces Ripk3- and macrophage-dependent beta-cell loss in zebrafish”

 

Dr. Qiang Wang, Institute of Zoology, Chinese Academy of Sciences, China

“ The origin and function of pharyngeal pouches during craniofacial development”

 

Zachary Brandt (PhD Candidate), Cell Biology Neurobiology and Anatomy, Medical College of Wisconsin, USA

“ Core Hippo pathway components act as a brake on Yap/Taz in the developing biliary network”

4:30pm – 4:50pm

Flash Talks (1 slide, 1 min/person); Chair: Dr. Han Wang (Soochow University, China)

 

ª Manoj Kumar Singh, Institute of Genomics and Integrative Biology, (P2-24)

ª Matthew R. Stoyek, Dalhousie University (P2-27)

ª Kandice Tanner, NCI,NIH (P2-28)

ª Paige Whyte-Fagundes, Department of Biology, York University (P2-33)

ª Seong-Kyu Choe,Wonkwang University School of Medicine(P3-39)

ª Rui Guan, ZCADD, St. Michael’s Hospital, (P3-40)

ª Saadet Mercimek-Andrews, The Hospital for Sick Children, (P3-46)

ª Kanagaraj Palsamy, Neurology, University of Michigan, (P3-47)

ª Peng Yang, Graduate School of Pharmaceutical Sciences, Chiba University, (P3-50)

ª Jan de Sonneville, Life Science Methods BV, Leiden, (P5-57)

5:00pm – 6:30pm

Dinner (2nd floor Exhibition hall, Room 240 & 241)

7:00pm – 10:00pm

Session IV: Poster Competition (1st floor CIBC Hall, Room 136)

Chair: Dr. Han Wang (Soochow University, China)

Friday, September 20th, 2019

7:30am – 8:50am

Breakfast (2nd floor Exhibition Hall, Room 240 & 241)

9:00am – 12:00pm

Session V: Chemical Biology, Pharmacogenomics, and Drug Discovery
Chair: Randall Peterson (University of Utah, USA)

9:00am – 9:30am

Invited Lecture (25 min + 5 min Q&A):

 

Dr. Jeff Mumm, Department of Ophthalmology, The John Hopkins University, USA

“ HTS-ready Degenerative Disease Modeling in Zebrafish”

9:30am – 10:15am

Oral Presentations (12 min + 3 min Q&A)

 

Dr. Edward Burton, University of Pittsburgh, USA

“ Unbiased phenotype-based chemical modifier screen in vivo reveals novel small molecule modulators of tauopathy”

 

Dr. Jyotshna Kanungo, US Food and Drug Administration, USA

“ Phenotype-Based Mechanistic Studies for the Assessment of Drug Safety and Drug-Drug Interactions in Zebrafish: Efficacy of Dietary Supplements”

 

Dr. Anju Philip (Postdoc), ZCADD & Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Canada

“ Preclinical development of a small molecule identified from a zebrafish screen as a novel candidate drug for sepsis targeting vascular leakage ”

10:15am – 10:30am

Coffee Break (2nd floor, Exhibition Hall)

 

10:30am – 11:00am

Invited Lecture (25 min + 5 min Q&A)

 

Dr. Yimon Aye , Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland

“ Keap-ing up your guard: renewed roles of Keap1 protein in innate immunity”

11:00am – 11:45am

Oral Presentations (12 min + 3 min Q&A)

 

Dr. Deborah Kurrasch, University of Calgary, Alberta Children’s Hospital, Hotchkiss Brain Institute, Canada

“ From zebrafish screening to clinical trial: the power of zebrafish in epilepsy drug discovery ”

 

Dr. Zhiyuan Gong Biological Sciences, National University of Singapore, Singapore

“ A zebrafish metastatic liver cancer model for screening of chemical drugs in suppression of tumor cell dissemination and migration”

 

Alaa Koleilat (PhD candidate), Mayo Clinic Graduate School of Biomedical Sciences, Minnesota, USA

“ Development of the First Pharmacotherapy for the Treatment of Usher Syndrome Type I due to Variants in MYO7A”

12:00pm – 1:00pm

Lunch (2nd floor, Exhibition Hall, Room 240 & 241)

1:30pm – 4:30pm

Session VI:   Translational Research & Drug Development

Chair: Dr. Xiao-Yan Wen (St. Michael’s Hospital, Unity Health Toronto & UofT, Canada)

1:30pm – 2:00pm

Invited Lecture (25 min + 5 min Q&A)

 

Dr. Karen Townsend, Torys LLP, Toronto, Canada

“ Emerging Legal Issues in Precision & Personalized Medicine”

2:00pm – 2:30pm

Dr. Hira Verma, Co-Founder and Board Chair, K.I.D.S. IQ Project, Toronto, Canada

“ The Rise of Parent-Driven Drug Discovery Efforts and Implications for Researchers and Clinicians”

2:30pm – 3:00pm

Dr. Calum MacRae, Brigham and Women’s Hospital & Harvard Medical School, USA

“ Changing the velocity of translation: co-clinical modeling of genotype and phenotype”

3:00pm – 3:15pm

Coffee Break (2nd floor, Exhibition Hall)

3:15pm – 3:45pm

Dr. Rita Fior, Champalimaud Centre for the Unknown, Portugal

“ Zebrafish Avatars towards personalized cancer treatments”

3:45pm – 4:15pm

Dr. Didier Stainier, Developmental Genetics, International Max Planck Research School for Heart and Lung Research, Germany

“ Cardiac regeneration in zebrafish”

4:15pm – 4:30pm

Award Presentations and Closing Remarks

ª Dr. Randall Peterson (Dean, College of Pharmacy, University of Utah, USA)

ª Dalton Charters (Senior Director, Research Operations, St. Michael’s Hospital, Canada)

5:30pm – 6:00pm

St. Michael’s Hospital (LKSKI Building) to Art Gallery of Ontario (AGO)

Address: 317 Dundas Street West, Toronto, Ontario, M5T 1G4

https://ago.ca

 

Transportation Options:

  1. Walk (20 mins)
  2. TTC- Public transport (15 mins)

6:00pm – 9:00pm

Networking Dinner at Galleria Italia Hall of Art Gallery of Ontario (AGO) and Announce of ZebraPeutics Award

9:00pm

Ending of Networking Dinner and Closure of AGO

           Walk to hotel (10 min)

 

3rd Zebrafish Neuroscience Workshop/Z-BRAIN Retreat

Wednesday, September 18th, 2019

12:00pm 1:00pm

Registration (2nd floor, Exhibition Hall)

 

1:00pm 1:10 pm

Welcome and Opening Remarks (Allan Waters Family Auditorium, Room 209)

ª Dr. Xiao-Yan Wen, Director, ZCADD, St. Michael’s Hospital

ª Dr. Tom Schweizer, Interim Director of Keenan Centre & Director of Neuroscience program, SMH

ª Dr. Jordan Antflick, Manager of Knowledge Translation, Ontario Brain Institute

1:10pm 2:30pm

Scientific Session A: Genetics/Modelling Chair: Dr. Edward Burton (University of Pittsburgh, USA)

1:10pm – 1:40pm

Invited Lecture (25 min + 5 min Q&A)

 

Dr. Harold Burgess, National Institute of Health (NICHD), USA

“ Systematic analysis of brain development and behavior in zebrafish autism models”

1:40pm – 2:20pm

Mini-talk (12 min + 3 min Q&A)

 

Dr. Gary Armstrong, Montreal Neurological Institute, Canada

“ Zebrafish tardbp and fus CRISPR knock-in models develop an ALS-like phenotype”

 

Dr. Maira Almeida, (PhD Candidate), Iowa State University and Mayo Clinic, USA

“ Short homology based CRISPR/Cas9 targeted integration to generate endogenous neural Cre drivers and conditional alleles in zebrafish”

 

Dr. Maximillian Breuer (Postdoc), INRS – Armand-Frappier Santé Biotechnologie Research Centre, Quebec, Canada

“ CHD7 regulates GABAergic network development ”

2:20pm – 2:40pm

Coffee Break (Back of Auditorium / Room 209)

2:40pm – 3:50pm

Scientific Session B: Physiology/Therapy, Chair: Dr. Marcia Taylor (Treventis Corp, Toronto, Canada)

2:40pm – 3:10pm

Dr. Scott Baraban, Department of Neurological Surgery, University of California San Francisco, USA

“ Precision medicine for epilepsy using zebrafish”

3:10pm – 3:50pm

Mini-talk (12 mins + 3 min Q&A)

 

Dr. Edward Burton, University of Pittsburgh, USA

“ Chemoptogenetic targeting of neuronal mitochondrial function in vivo”

 

Dr. Gabriel Bosse, (Postdoc), College of Pharmacy, University of Utah, USA

“ Identification of a role for neurosteroids in addiction using an opioid self-administration assay”

 

 

Dr. Leonor Saude Instituto de Medicina Molecular, Lisboa, Portugal

“ A zebrafish drug screening platform boosts the discovery of novel therapeutics for spinal cord injury in mammals ”

3:50pm – 3:55pm

Closing Remarks: Dr. Edward Burton (University of Pittsburgh, USA)