Conference Program

3rd Zebrafish for Personalized/Precision Medicine Conference

September 27-29, 2017
Wednesday September 27, 2017
6:00pm – 8:30pm Session I: Advances in Zebrafish Research & Precision Medicine (Opening Lectures, Co-chairs: Xiao-Yan Wen & Ian Scott)
Invited Lectures (30 min/lecture):
(1) Michael Wilson, PhD, The Hospital for Sick Children & University of Toronto
“From mammals to fish and back again: using comparative epigenomics to discover ancient enhancers active in early heart development”
(2) Lila Solnica-Krezel, PhD, Washington University School of Medicine in St. Louis
“Forward and Reverse Genetic Approaches to Scoliosis in Zebrafish”
(3) Peter Liu, MD, University of Ottawa Heart Institute, Canada
“Search for Novel Biomarkers and Biotargets for Precision Medicine in Heart Disease”
(4) Stephen Ekker, PhD, Mayo Clinic, Rochester, USA
“Engineering the Power House of the Cell”
Thursday September 28 2017
9:00am – 12:00pm Session II: Mutagenesis & Disease Modeling (Chair: Stephen Ekker)
A. Invited Lectures: (30 min/lecture)
(1) Erica Davis, Center for Human Disease Modeling, Duke University
“Functional dissection of pediatric genetic diseases”
(2) Jeff Essner, PhD, Iowa State University
“Enhanced efficiencies using short regions of homology for precise DNA integration in zebrafish”
B. 6 mini-talks selected from abstracts (15 min/talk)

(1) PI talks
Keith C. Cheng, MD, PhD, Penn State College of Medicine, USA
“From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics”

Raman Sood, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA
“Multiplexed CRISPR/Cas9-mediated knockout of nineteen Fanconi anemia pathway genes to understand their roles in disease pathophysiology”

Weibin Zhou, University of Michigan, USA
“Characterization of a new zebrafish model of finnish-type nephrotic syndrome”

(2) Trainee talks
Han B. Lee (PhD Candidate), Mayo Clinic Graduate School of Biomedical Sciences; Mayo Clinic, Rochester, USA
“Development of a dual-light assay system to identify genetic or epigenetic modifiers of the hypothalamic-pituitary-adrenal axis”

Onofrio Laselva (Postdoc), Programme in Molecular Medicine, Hospital for Sick Children, University of Toronto, Canada
“Studying the distinct sensitivities of CFTR modulators using Zebrafish-CFTR”

Ivo Eijkenboom(PhD candidate), Maastricht University Medical Centre, Maastricht, The Netherlands
“A zebrafish model for small-fiber neuropathy”
1:30pm – 4:30pm Session III. Mechanisms of Development, Organ Dysfunction & Disease (Chair: Oliver Bandmann)
A. Invited Lectures: (30 min/lecture)
(1) Catarina Henriques, University of Sheffield, UK
“Telomeres, telomerase and inflammation in zebrafish ageing”
(2) Marie-Andrée Akimenko, University of Ottawa, Canada
“Gene regulation of joint formation in regenerating fins”
B. 6 mini-talks selected from abstracts (15 min/talk)

(1) PI talks
Ela Knapik, Vanderbilt Genetics Institute, VUMC, Nashville, TN, USA
“Disease Mechanism Discovery: Iteration among a Biobank, Zebrafish, and Electronic Health Records”

Peng Huang, University of Calgary, Calgary, Alberta, Canada
“In vivo dynamics of muscle-associated cells during zebrafish muscle regeneration”

Han Wang, Center for Circadian Clocks, Soochow University, China
“Rhythmically expressed histone methyltransferase enhancer of zeste homolog 2 (ezh2) enhances circadian regulation and hematopoiesis through binding to clock proteins independent of its histone methyltransferase activity in zebrafish”

Marika Kapsimali, IBENS, INSERM-U1024, Paris, France
“The zebrafish taste sensory cells: a screening tool for harmful chemicals and compounds enhancing regeneration”

(2) Trainee talks
Tamjid A. Chowdhury (Postdoc), Medical College of Wisconsin, Milwaukee, USA
“Temporal and spatial post-transcriptional regulation of zebrafish tie-1 mRNA by long non-coding RNA”

Yahui Lan (Postdoc), Weill Cornell Medical College, New York, USA
“Epigenetic Control of Zebrafish Cardiogenesis by TET2/3”
7:30pm – 10:30pm Session IV. Poster Session (Chair: Ian Scott)
Friday September 29, 2017
9:00am – 12:00pm Session V. Chemical Biology, Pharmacogenomics & Drug Discovery (Chair: Randall Peterson)
A. Invited Lectures: (30 min/lecture)
(1) Pierre Drapeau, University of Montreal, Canada
“Neuroleptics for ALS: small compound screen and small clinical trial”
(2) Edward Burton, MD, DPhil, FRCP, Neurology, University of Pittsburgh, USA
“Unbiased phenotype-based chemical modifier screens in zebrafish models of neurodegenerative movement disorders”
B. 6 mini-talks selected from abstracts (15 min/talk)

(1) PI talks
Oliver Bandmann, University of Sheffield, UK
“Gene-gene interaction studies in a zebrafish model of Gaucher disease”

Martin Distel, Children’s Cancer Research Institute, Zimmermannplatz 10, 1090 Vienna, Austria
“A zebrafish model mimicking aspects of Costello Syndrome amenable to compound screening”

Richard Glenn dela Cruz , Oklahoma Medical Research Foundation, Oklahoma City, USA
“Identification of novel inhibitors of the activated Wnt/β-catenin signaling pathway using the developing zebrafish embryo”

(2) Trainee talks
Purnima Manghnani (PhD candidate), National University of Singapore
“Zebrafish as a predictive model for photodynamic therapy”

Charles H Williams (Postdoc), Vanderbilt University Medical Center, USA
“ZePASS (Zebrafish Phenotypic Anatomical Similarity System) Guides Target Identification of a Wnt Inhibitor Incaskin, a Novel, Highly Selective CK2α Kinase Inhibitor”

Arman Hassanpour, (M.Sc. candidate), Institute of Medical Science, University of Toronto & Zebrafish Centre for Advanced Drug Discovery, St. Michael’s Hospital, Canada
“Preclinical development of drugs for intracerebral hemorrhage (ICH)”
1:30pm – 5:00pm Session VI. Translational Research & Drug Development (Closing Lectures, Chair: Xiao-Yan Wen)
Invited Lectures (30 min/lecture):
(1) Ori Rotstein, Director, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
“Using zebrafish to study mechanisms of inflammation”
(2) Charles Hong, MD, PhD, Pharmacology, Cell and Developmental Biology, Vanderbilt University, USA
“Chemical Genetics of Zebrafish Embryonic Development to Drive Therapeutic Target Discovery in Man”
(3) Clara van Karnebeek, MD, PhD. University of Amsterdam, Netherlands
“Zebrafish modelling for Neurometabollic diseases: Identification of disease mechanisms & treatment targets”
(4) Yibin Feng, Associate Director, School of Chinese Medicine, The University of Hong Kong
“Drug discovery from Chinese medicines: the past, present and future”
(5) Randall Peterson, Dean, College of Pharmacy, University of Utah, USA
“Modeling human CNS disorders in the zebrafish.”
6:30pm – 9:30pm Networking Dinner at Ripley’s Aquarium of Canada

2nd Zebrafish Neuroscience Workshop

9:00am to 12:00pm, Sept 27, 2017
A. Invited Plenary Talks (20 min/lecture):
Karl Clark, PhD, Mayo Clinic at Rochester, Minnesota, USA
“Targeted mutagenesis and analysis of the vertebrate stress response in Danio rerio”
Anne Dekeyne, Institute of Research Servier, Paris, France
“Zebrafish as a tool for target validation and drug discovery in proteinopathies of the CNS”
Alexander Jodey Parker, PhD. University of Montreal, Canada
“Early drug discovery and development for neurological disorders using C. elegans”
B. PI Talks (10 min/talk)
Ted Allison, PhD. University of Alberta, Canada
“Towards stem cell therapy of blindness: Defining gene regulatory networks in the premier genetic model of cone photoreceptors”
Lee Ellis, PhD, National Research Council of Canada
“Assessing the uptake kinetics, biological activity and potential interaction of individual cannabinoids using zebrafish larvae”
Peng Huang, PhD, University of Calgary, Canada
“PHRESH analysis of cell signaling dynamics during spinal cord patterning”
Tod Thiele, PhD, University of Toronto Scarborough, Canada
Investigation of neural circuits controlling action selection in larval zebrafish”
Han Wang, PhD, Center for Circadian Clocks, Soochow University, Suzhou, China
“A circadian model for major depressive disorder (MDD)”
C. Trainee Talks (10 min/talk)
Khang Hua (PhD candidate), University of Ottawa, Canada
“Elucidating Molecular Changes During Dopaminergic Neuron Regeneration in Zebrafish”
Justin W. Kenney (Postdoc), Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
“Towards the generation of a digital adult zebrafish brain atlas”
Éric Samarut (Postdoc), CRCHUM, Montréal, QC, Canada
“Light-induced generalized epilepsy in gabra1 knockout zebrafish: a simple model for unravelling the molecular basis of epilepsy and screening for anti-epileptic drugs”
Brock Schuman (Postdoc), Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre of St. Michael’s Hospital, Toronto, Canada
“Zebrafish Models of Parkinson’s Disease”